The Marine Biological Laboratory
Home
Directory
JBPC Forms
JBPC Wiki
The Marine Biological Laboratory The Marine Biological Laboratory
 
Faculty
Mitchell Sogin
Joshua Hamilton
Julie Huber
David Mark Welch
David Patterson
Anton Post
Jennifer Wernegreen
Research Faculty
Mark Alliegro
Linda Amaral Zettler
Irina Arkhipova
Hilary Morrison
William Reznikoff
Margrethe (Gretta) Serres
Adjunct Faculty
Marlene Belfort
Seth Bordenstein
Robert Campbell
Matthew Meselson
Andreas Teske
Harold Zakon
MBL/Brown Faculty
David Rand
Gary Wessel
Other Personnel
Visiting Scientists
Administration
Graduate Students
Postdoctoral Fellows
Informaticists
Computer Facilities
Computer Resources
Sequencing Informatics
Software
Databases
Beowulf Clusters
Personnel
Local Databases
Antonospora locustae
GenProtEC
GiardiaDB
ICOMM
Micro*Scope
Spraguea lophii
Education
Advances in Genome Technology and Bioinformatics
Workshop on Molecular Evolution
Brown-MBL Graduate Program
Living in the Microbial World
HHMI-MBL Precollege Science Education Lab Series
Protistology Workshop

THE JOSEPHINE BAY PAUL CENTER IN COMPARATIVE MOLECULAR BIOLOGY AND EVOLUTION was officially established at the Marine Biological Laboratory in January of 1997. It is made possible by a generous endowment from the Josephine Bay Paul and C. Michael Paul Foundation which has had a philanthropic interest in the MBL for the past twenty years.   Read more...

RESEARCH at the Center explores the evolution and interaction of genomes of diverse organisms that play significant roles in environmental biology and human health. Projects span all evolutionary time scales, from deep phylogenetic divergence of ancestral prokaryotic and eukaryotic lineages to ecological analyses of how members of diverse communities contribute and respond to environmental change.
The Center also houses the Mobile Genetic Element Cluster, which includes MBL-affiliated year-round and summer investigators who are studying mobile DNA, and the Imaging Microbial Diversity Cluster, which includes Bay Paul Center and other MBL investigators who are developing new methods to visualize the diversity of microbes and their spatial relationship.

The Center is part of the Brown University - Marine Biological Laboratory Graduate Program in Biological and Environmental Sciences. Most faculty are currently accepting students.


Bay Paul Center Seminar Series:

TBD
TBD
Josephine Bay Paul Center, MBL

Friday November 14th, 2008, at noon in Candle House 104/105


Recent Publications:

B.J.F. Keijser, E. Zaura, S.M. Huse,J.M.B.M. van der Vossen, F.H.J. Schuren,R.C. Montijn, J.M. ten Cate, and W. Crielaard. 2008. Pyrosequencing analysis of the oral microflora of healthy adults. Journal of Dental Research 87(11):1016-1020, 2008

Fernan Aguero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S. Buckner, Robert K. Campbell, Santiago Carmona, Ian M. Carruthers, A. W. Edith Chan, Feng Chen, Gregory J. Crowther, Maria A. Doyle, Christiane Hertz-Fowler, Andrew L. Hopkins, Gregg McAllister, Solomon Nwaka, John P. Overington, Arnab Pain, Gaia V. Paolini, Ursula Pieper, Stuart A. Ralph, Aaron Riechers, David S. Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C. Van Voorhis and Christophe L. M. J. Verlinde. Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery Volume 7, November 2008, 900-907.

San Gil, I., Sheldon,W., Schmidt, T., Servilla, M., Aguilar, R., Gries, C., Gray, T., Field, D., Cole, J., Yun Pan, J., Palanisamy, G., Henshaw, D., O'Brien, M., Kinkel, L., McMahon, K., Kottmann, R., Amaral-Zettler, L., Hobbie, J., Goldstein, P., Guralnick, R. P., Brunt, J., and Michener W. K., Defining linkages between the GSC and NSF's LTER program: How the Ecological Metadata Language (EML) relates to GCDML and other outcomes. 2008. OMICS A Journal of Integrative Biology,12(2):151-156.

Huber, J.A. and J.F. Holden. 2008. Modeling the impact of diffuse vent microorganisms along mid-ocean ridges and flanks. In Lowell, R.P., J. S. Seewald, A. Metaxas, and M.R. Perfit (eds.), 215-231. Magma to Microbe: Modeling Hydrothermal Processes at Oceanic Spreading Ridges. American Geophysical Union Press, Washington, D.C.

Tamas, I., J. J. Wernegreen, B. Nystedt, S. N. Kauppinen, A. C. Darby, L. Gomez-Valero, D. Lundin, A. M. Poole and S. G. Andersson (2008). "Endosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tracts." Proc Natl Acad Sci U S A 105(39): 14934-9.

Cristina Aurrecoechea, John Brestelli, Brian P. Brunk, Jane M. Carlton, Jennifer Dommer, Steve Fischer, Bindu Gajria, Xin Gao, Alan Gingle, Greg Grant, Omar S. Harb, Mark Heiges, Frank Innamorato, John Iodice, Jessica C. Kissinger, Eileen Kraemer, Wei Li, John A. Miller, Hilary G. Morrison, Vishal Nayak, Cary Pennington, Deborah F. Pinney, David S. Roos, Chris Ross, Christian J. Stoeckert, Jr, Steven Sullivan, Charles Treatman and Haiming Wang. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis Nucleic Acids Res. First published online 29 Sep 2008; doi:10.1093/nar/gkn631

Fredrickson, J.K., Romine, M.F., Beliaev, A.S., Auchtung, J.M., Driscoll, M.E., Gardner, T.S., Nealson, K.H., Osterman, A.L., Pinchuk, G., Reed, J.L., Rodionov, D.A., Rodrigues, J.L., Saffarini, D.A., Serres, M.H., Spormann, A.M., Zhulin, I.B., Tiedje, J.M. (2008). Towards environmental systems biology of Shewanella. Nature Reviews Microbiology, 2008 Aug;6(8):592-603..

Lasek-Nesselquist, E., A. Bogomolni, R. Gast, D. Mark Welch, J.C. Ellis, M.L. Sogin, and M. Moore. 2008. Molecular characterization of Giardia intestinalis in marine animals: variation and zoonotic potential. Diseases of Aquatic Organisms 81: 39-51.

E.A. Gladyshev, M. Meselson, and I.R. Arkhipova (2008) Massive horizontal gene transfer in bdelloid rotifers. Science 320: 1210-1213.

Cara M. Santelli, Beth N. Orcutt, Erin Banning, Wolfgang Bach, Craig L. Moyer, Mitchell L. Sogin, Hubert Staudigel & Katrina J. Edwards Abundance and diversity of microbial life in ocean crust Nature 453, 653-656 (29 May 2008)

N. Schostak, K. Pyatkov, E. Zelentsova, I. Arkhipova, D. Shagin, E. Mudrik, A. Blintsov, I. Clark, D.J. Finnegan, M. Evgen'ev (2008) Molecular dissection of Penelope transposable element regulatory machinery. Nucleic Acids Res. 36(8): 2522-2529

Suga, K., D. B. Mark Welch, Y. Tanaka, Y. Sakakura, and A. Hagiwara, 2008. Two circular chromosomes of unequal copy number make up the mitochondrial genome of the rotifer Brachionus plicatilis. Molecular Biology and Evolution 2008 25: 1129-1137.

Manda Clair Jost, David M. Hillis, Ying Lu, John W. Kyle, Harry A. Fozzard, and Harold H. Zakon, 2008. Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family Molecular Biology and Evolution 2008 25: 1016-1024; doi:10.1093/molbev/msn025.

Riley M., Staley J.T., Danchin A., Wang T., Brettin T.S., Hauser L.J., Land M.L., Thompson L.S. Genomics of an extreme psychrophile, Psychromonas ingrahamii. BMC Genomics. 2008 May 6;9(1):210 PMID: 18460197.

Alliegro, M., Alliegro, M. A., 2008. Centrosomal RNA correlates with intron-poor nuclear genes in Spisula oocytes. Proceedings of the National Academy of Sciences 105:6993-6997.

Amaral Zettler, L. A., Peplies, J., Ramette, A. Fuchs, B., Ludwig, W., and Glšckner, F. O., Proceedings of the International Workshop on Ribosomal RNA Technology, April 7-9, 2008, Bremen, Germany, 2008. Syst. Appl. Microbiol. 31(4): 258-268.

Rull, K., Hallast, P., Uuskula, L., Jackson, J., Punab, M., Salumets, A., Campbell, R.K., and Laan, M. Fine scale quantification of hCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Mol. Human Reprod. 14:23-31. (2008) E-published November 29, 2007.

McKenna, S.D., Feger, G., Kelton, C., Yang, M., Ardissone, V., Cirillo, R., Vitte, P.A., Jiang, X., and Campbell, R.K. Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist. J. Pharmacol Exp. Ther. 322:822-828. (2007)

Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing. PLoS Biol 6(11): e280 doi:10.1371/journal.pbio.0060280

Gladyshev, E., Meselson, M., 2008. Extreme resistance of bdelloid rotifers to ionizing radiation Proceedings of the National Academy of Sciences 10.1073/pnas.0800966105

Huse, S. M., J. A. Huber, Morrison, H. G., Sogin, M.L., Mark Welch, D. (2007). Accuracy and quality of massively-parallel DNA pyrosequencing. Genome Biology 8: R143.

Driscoll, M.E., Romine, M.F., Juhn, F.S., Serres, M.H., McCue, L.A., Beliaev, A.S., Fredrickson, J.K., Gardner, T.S. (2007). Identification of diverse carbon utilization pathways in Shewanella oneidensis MR-1 via expression profiling. Genome Informatics, 2007;18:287-98..

 
 
     
Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Department of Energy.
Unless otherwise stated, all material © 2007 Bay Paul Center, MBL.